Detailed explanation of the relationship between oncogene and human genes

The cure rate of late stage tumors is less than 20%, and if discovered in the first stage, the cure rate can reach as high as 95%. The reason why the mortality rate of cancer remains high is because it is found to be very difficult to treat in the middle and late stages. With the development of medicine, people have found the relationship between genes and tumors. Through gene examination, tumor indicators can be found, which can greatly improve the Lebensraum of patients.

The following will take you to understand the common sense of oncogene detection and human genes.

What is the relationship between genes and tumors?

Human growth is a very complex process, where we only see changes in appearance with the naked eye from year to year, but the cells in the body are changing every day. And its changes are related to personal lifestyle habits, dietary habits, aging, living environment, and emotions, any of which may cause damage to the human body's DNA, leading to genetic mutations.

Once a gene related to tumors undergoes a mutation, healthy cells in the human body will be affected, gradually developing from qualitative transformation to cancerous transformation, and ultimately forming tumor cells in the body.

So tumors start with a small genetic mutation.

When it comes to cancer, everyone only knows that the mortality rate is particularly high, but they do not understand what kind of disease cancer is.

In fact, cancer cannot be said to be a disease, it is an endogenous cell that undergoes genetic mutations. Like other infectious diseases, it is caused by abnormal cell growth. Healthy individuals, mature cells in their bodies will work in a systematic manner for the human body, but under adverse stimuli, healthy cells undergo abnormal differentiation or growth, and are not controlled by the body. These abnormal cells accumulate and develop in the body, which can also undermine the focus of physical health work. Therefore, cancer is caused by genetic mutations, also known as genetic diseases by medical experts.

Having discovered this relationship, scientists say that gene detection can protect people's health and reduce the incidence rate of cancer, but people still have a vague concept of gene detection. What is it?

02. What is genetic testing?

In fact, to put it simply, it means checking for normal genes in the human body. For example, if a pig in a pig herd experiences a plague, it will affect other healthy pigs and cause infections in the surrounding pigs. If the presence of plague pigs can be detected early, it can reduce losses and ensure the safety of other pigs.

So the purpose of genetic testing is to discover mutated genes in the body, prevent them from damaging healthy cells in the human body. Through advanced testing methods, "bad" genes can be clearly detected, and it is also widely used in clinical practice. A single test can detect millions of DNA components. Its characteristics are: wide inspection range, accuracy, and low cost.

03. Gene testing is mainly applied in three major fields

Currently, precise medical treatment for tumors, infection, and eugenics are the three hot areas of genetic testing:

In the application of tumor precision medicine, NGS (Gene Second Generation Sequencing) can play a role in the entire process of tumor genetic risk detection, early screening, concomitant diagnosis, immunotherapy/targeted therapy medication guidance, postoperative recurrence monitoring, etc., to help achieve "early detection, diagnosis, and treatment" of tumors.

At the infection line, NGS is used for database comparison and bioinformatics analysis to complete the detection of pathogens such as bacteria, fungi, viruses, and parasites in one go. And it does not require specific amplification, especially suitable for the diagnosis of critical and difficult infections.

In the field of eugenics, NGS can mainly carry out pre implantation genetic testing (PGT), cfDNA based non-invasive prenatal testing (NIPT), DNA methylation research, neonatal gene screening, etc. For example, screening for folate metabolism, non-invasive prenatal genetic testing, screening for chromosomal abnormalities, and screening for genetic diseases, which we are familiar with, can effectively avoid birth defects in fetuses.

04. What is the value of genetic testing for the general public?

For healthy individuals, regular genetic testing can detect lesions early and is an important means of cancer prevention screening. The more timely the disease is detected, the faster it recovers, and the higher the cure rate.

For people infected with tumors, it can effectively prevent recurrence and metastasis, and also provide great help in precise medication.

Doctors remind that the following groups require genetic testing

Having a family genetic history

People who smoke and drink for a long time

The working environment is harsh and the air pollution in the environment is severe

Middle aged and elderly people over 45 years old

Patients with underlying diseases, such as enteritis and lung diseases

Patients who have been diagnosed with tumors and have undergone treatment surgery

Due to work reasons, a group with long-term black and white reversals

05. Is it possible to develop tumors due to genetic mutations?

Most patients have the misconception that if abnormal genes are found during the examination, they believe that they will definitely develop cancer in the future.

In fact, gene mutations ≠ tumors, while tumors=gene mutations. In clinical practice, only some gene mutations can form tumors. Only those that have been confirmed to have a definite relationship with tumors require drug intervention treatment.